The genetic landscape of Alzheimer disease: clinical implications and perspectives.

Genet Med. 2015 Aug 27. doi: 10.1038/gim.2015.117. [Epub ahead of print] Van Cauwenberghe C1,2, Van Broeckhoven C1,2, Sleegers K1,2. Abstract The search for the genetic factors contributing to Alzheimer disease (AD) has evolved tremendously throughout the years. It started from the discovery of fully penetrant mutations in Amyloid precursor protein, Presenilin 1, and Presenilin 2(…)