Tudományos kitekintés – Daganatok

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

Cancers are caused by mutations that may be inherited, induced by environmental factors, or result from DNA replication errors (R). We studied the relationship between the number of normal stem cell divisions and the risk of 17 cancer types in 69 countries throughout the world. The data revealed a strong correlation (median = 0.80) between(…)

CRISPR gene-editing tested in a person for the first time

The move by Chinese scientists could spark a biomedical duel between China and the United States. David Cyranoski A Chinese group has become the first to inject a person with cells that contain genes edited using the revolutionary CRISPR–Cas9 technique. On 28 October, a team led by oncologist Lu You at Sichuan University in Chengdu(…)

Personalized medicine in gastric cancer: Where are we and where are we going?

Jácome AA, Coutinho AK, Lima EM, Andrade AC, Dos Santos JS. Abstract Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of(…)

Toward precision medicine of breast cancer.

Carels N, Spinassé LB, Tilli TM, Tuszynski JA. Abstract In this review, we report on breast cancer’s molecular features and on how high throughput technologies are helping in understanding the dynamics of tumorigenesis and cancer progression with the aim of developing precision medicine methods. We first address the current state of the art in breast(…)

Új lehetőségek rosszindulatú daganatok személyre szabott terápiájában

2016. február 3. Forrás: MTA Az MTA és a Semmelweis Egyetem Bödör Csaba vezette Lendület Molekuláris Onkohematológiai Kutatócsoportjának részvételével új mutációs és lehetséges terápiás célpontot azonosítottak follikuláris limfómában a londoni Barts Cancer Institute kutatói. Eredményeiket a Nature Geneticsben közölték. A frissen felfedezett genetikai eltérések az mTOR jelátviteli út komponenseiben, az RRAGC, valamint az ATP6AP1 és(…)

Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials.

J Clin Oncol. 2015 Nov 10;33(32):3817-25. doi: 10.1200/JCO.2015.61.5997. Epub 2015 Aug 24. Schwaederle M1, Zhao M2, Lee JJ2, Eggermont AM2, Schilsky RL2, Mendelsohn J2, Lazar V2, Kurzrock R2. Abstract PURPOSE: The impact of a personalized cancer treatment strategy (ie, matching patients with drugs based on specific biomarkers) is still a matter of debate. METHODS: We(…)

Prognostic and predictive immune gene signatures in breast cancer.

Curr Opin Oncol. 2015 Nov;27(6):433-44. doi: 10.1097/CCO.0000000000000234. Bedognetti D1, Hendrickx W, Marincola FM, Miller LD. Abstract PURPOSE OF REVIEW: Here, we focus on molecular biomarkers derived from transcriptomic studies to summarize the recent advances in our understanding of the mechanisms associated with differential prognosis and treatment outcome in breast cancer. RECENT FINDINGS: Breast cancer is(…)

Recent advances in the molecular diagnostics of gastric cancer.

World J Gastroenterol. 2015 Sep 14;21(34):9838-52. doi: 10.3748/wjg.v21.i34.9838. Kanda M1, Kodera Y1. Abstract Gastric cancer (GC) is the third most common cause of cancer-related death in the world, representing a major global health issue. Although the incidence of GC is declining, the outcomes for GC patients remain dismal because of the lack of effective biomarkers(…)

A 2015 update on predictive molecular pathology and its role in targeted cancer therapy: a review focussing on clinical relevance.

Cancer Gene Ther. 2015 Sep;22(9):417-30. doi: 10.1038/cgt.2015.39. Epub 2015 Sep 11. Dietel M1, Jöhrens K1, Laffert MV1, Hummel M1, Bläker H1, Pfitzner BM1, Lehmann A1, Denkert C1, Darb-Esfahani S1, Lenze D1, Heppner FL2, Koch A2, Sers C1, Klauschen F1, Anagnostopoulos I1. Abstract In April 2013 our group published a review on predictive molecular pathology in(…)

Molecular epidemiology, and possible real-world applications in breast cancer.

Breast Cancer. 2015 Apr 11. [Epub ahead of print] Ito H1, Matsuo K. Abstract Gene-environment interaction, a key idea in molecular epidemiology, has enabled the development of personalized medicine. This concept includes personalized prevention. While genome-wide association studies have identified a number of genetic susceptibility loci in breast cancer risk, however, the application of this(…)